Gamma Knife Surgery for Brain Metastasis from Hepatocellular Carcinoma

The authors evaluated the results of Gamma knife surgery (GKS) for the treatment of metastatic brain tumors from hepatocellular carcinoma (HCC).). The mean marginal dose prescribed was 18.7±3.2 Gy (range 10.0–22.0 Gy). The mean number of shots administered was 10±9 (range 1–27). The median overall survival time after GKS was 5.0±0.93 months (95% CI 3.2–6.8). No complications related to the radiosurgical treatment were identified. Multivariate analysis showed that the total volume of brain metastases, the RTOG RPA class and serum AFP level were significantly correlated with patients’ survival time.Although survival was extremely poor in patients with brain metastasis (BM) from HCC, GKS was shown to lead to prolongation of the survival time. Accordingly, GKS can be considered as a valuable treatment option for proper patients with HCC BM