. Approximately 20–30% of the genes are estimated to be scrambled in the germline micronucleus, with coding segment order permuted and present in either orientation on micronuclear chromosomes. Massive genome rearrangements are therefore critical for development.To understand the process of DNA deletion and reorganization during macronuclear development, we examined the population of DNA molecules during assembly of different scrambled genes in two related organisms in a developmental time-course by PCR. The data suggest that removal of conventional IESs usually occurs first, accompanied by a surprising level of error at this step. The complex events of inversion and translocation seem to occur after repair and excision of all conventional ...
Chromoanagenesis is a catch-all term of recently described catastrophic events that generate complex...
Ciliates are a type of unicellular eukaryotic organism that has two types of nuclei within each cell...
Foldback inversions, also called inverted duplications, have been observed in human genetic diseases...
Programmed DNA elimination and reorganization frequently occur during cellular differentiation. Deve...
Some genera of ciliates, such as Oxytricha and Stylonychia, undergo massive genome reorganization du...
Some genera of ciliates, such as Oxytricha and Stylonychia, undergo massive genome reorganization du...
SummaryProgrammed DNA rearrangements in the single-celled eukaryote Oxytricha trifallax completely r...
Programmed DNA rearrangements in the single-celled eukaryote Oxytricha trifallax completely rewire i...
Programmed DNA rearrangements in the single-celled eukaryote Oxytricha trifallax completely rewire i...
Motivation: A detailed study of deletion and insertion mutagenesis could improve our understanding o...
The now-classical model of replication slippage can in principle account for both simple deletions a...
<p>For the gene deletions in patient 1, gene rearrangements exhibiting deletions due to non-homologo...
The now-classical model of replication slippage can in principle account for both simple deletions a...
Ciliates are a type of unicellular eukaryotic organism that has two types of nuclei within each cell...
Ciliates are a type of unicellular eukaryotic organism that has two types of nuclei within each cell...
Chromoanagenesis is a catch-all term of recently described catastrophic events that generate complex...
Ciliates are a type of unicellular eukaryotic organism that has two types of nuclei within each cell...
Foldback inversions, also called inverted duplications, have been observed in human genetic diseases...
Programmed DNA elimination and reorganization frequently occur during cellular differentiation. Deve...
Some genera of ciliates, such as Oxytricha and Stylonychia, undergo massive genome reorganization du...
Some genera of ciliates, such as Oxytricha and Stylonychia, undergo massive genome reorganization du...
SummaryProgrammed DNA rearrangements in the single-celled eukaryote Oxytricha trifallax completely r...
Programmed DNA rearrangements in the single-celled eukaryote Oxytricha trifallax completely rewire i...
Programmed DNA rearrangements in the single-celled eukaryote Oxytricha trifallax completely rewire i...
Motivation: A detailed study of deletion and insertion mutagenesis could improve our understanding o...
The now-classical model of replication slippage can in principle account for both simple deletions a...
<p>For the gene deletions in patient 1, gene rearrangements exhibiting deletions due to non-homologo...
The now-classical model of replication slippage can in principle account for both simple deletions a...
Ciliates are a type of unicellular eukaryotic organism that has two types of nuclei within each cell...
Ciliates are a type of unicellular eukaryotic organism that has two types of nuclei within each cell...
Chromoanagenesis is a catch-all term of recently described catastrophic events that generate complex...
Ciliates are a type of unicellular eukaryotic organism that has two types of nuclei within each cell...
Foldback inversions, also called inverted duplications, have been observed in human genetic diseases...