Mangafodipir is a contrast agent used in magnetic resonance imaging that concentrates in the liver and displays pleiotropic antioxidant properties. Since reactive oxygen species are involved in ischemia-reperfusion damages, we hypothesized that the use of mangafodipir could prevent liver lesions in a mouse model of hepatic ischemia reperfusion injury. Mangafodipir (MnDPDP) was compared to ischemic preconditioning and intermittent inflow occlusion for the prevention of hepatic ischemia-reperfusion injury in the mouse.Mice were subjected to 70% hepatic ischemia (continuous ischemia) for 90 min. Thirty minutes before the ischemic period, either mangafodipir (10 mg/kg) or saline was injected intraperitoneally. Those experimental groups were com...
<p>The concentrations of glutathione in cytoplasm and mitochondria of mouse liver were measured spec...
<p>Perfusate Purine Nucleotide Phosphorylase (PNP) activity (A) and tissue accumulation of Nitrate/n...
The purpose of this study was to investigate the possible protective effect of N-acetylserotonin (N...
Mangafodipir is a contrast agent used in magnetic resonance imaging that concentrates in the liver a...
Introduction and Aim: Mangafodipir is a contrast agent used in magnetic resonance imaging that conce...
*<p>Animal survival was evaluated using the model of total hepatic ischemia (37).</p><p>The rate of ...
<p>Hematoxylin-eosin-stained sections were used for histopathological evaluation of hepatic injuries...
Ischemia/reperfusion injury occurring during liver transplantation is mainly due to the generation o...
Ischemia/reperfusion injury occurring during liver transplantation is mainly due to the generation o...
<p>(A) Hepatic malondialdehyde (MDA) levels and Catalase (B) and superoxide dismutase (C) activities...
<p>(A) TUNEL staining of livers (original magnification ×40) and (B) Percentage of TUNEL-positive he...
<p>(A) GLDH perfusate levels were measured in livers harvested from untreated rats and immediately s...
<p>(A) Hepatic ATP content were measured in normal livers, in livers procured from sodium chloride s...
<p>(A) Alanine amino transferase (ALT), Aspartate amino transferase (AST) and Lactate dehydrogenase ...
<p>Hematoxylin eosin stained sections were used for the evaluation of histological lesions (A) (magn...
<p>The concentrations of glutathione in cytoplasm and mitochondria of mouse liver were measured spec...
<p>Perfusate Purine Nucleotide Phosphorylase (PNP) activity (A) and tissue accumulation of Nitrate/n...
The purpose of this study was to investigate the possible protective effect of N-acetylserotonin (N...
Mangafodipir is a contrast agent used in magnetic resonance imaging that concentrates in the liver a...
Introduction and Aim: Mangafodipir is a contrast agent used in magnetic resonance imaging that conce...
*<p>Animal survival was evaluated using the model of total hepatic ischemia (37).</p><p>The rate of ...
<p>Hematoxylin-eosin-stained sections were used for histopathological evaluation of hepatic injuries...
Ischemia/reperfusion injury occurring during liver transplantation is mainly due to the generation o...
Ischemia/reperfusion injury occurring during liver transplantation is mainly due to the generation o...
<p>(A) Hepatic malondialdehyde (MDA) levels and Catalase (B) and superoxide dismutase (C) activities...
<p>(A) TUNEL staining of livers (original magnification ×40) and (B) Percentage of TUNEL-positive he...
<p>(A) GLDH perfusate levels were measured in livers harvested from untreated rats and immediately s...
<p>(A) Hepatic ATP content were measured in normal livers, in livers procured from sodium chloride s...
<p>(A) Alanine amino transferase (ALT), Aspartate amino transferase (AST) and Lactate dehydrogenase ...
<p>Hematoxylin eosin stained sections were used for the evaluation of histological lesions (A) (magn...
<p>The concentrations of glutathione in cytoplasm and mitochondria of mouse liver were measured spec...
<p>Perfusate Purine Nucleotide Phosphorylase (PNP) activity (A) and tissue accumulation of Nitrate/n...
The purpose of this study was to investigate the possible protective effect of N-acetylserotonin (N...