mutations, efforts in trying to link CD genetics to clinical subphenotypes have not been very successful. We hypothesized that the large number of confirmed genetic variants enables (better) classification of CD patients.To look for genetic-based subgroups, genotyping results of 46 SNPs identified from CD GWAS were analyzed by Latent Class Analysis (LCA) in CD patients and in healthy controls. Six genetic-based subgroups were identified in CD patients, which were significantly different from the five subgroups found in healthy controls. The identified CD-specific clusters are therefore likely to contribute to disease behavior. We then looked at whether we could relate the genetic-based subgroups to the currently used clinical parameters. A...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
mutations, efforts in trying to link CD genetics to clinical subphenotypes have not been very succe...
Background: Crohn's Disease (CD) has a heterogeneous presentation, and is typically classified accor...
Background Crohn's Disease (CD) has a heterogeneous presentation, and is typically classified accor...
Complex human diseases commonly differ in their phenotypic characteristics, e.g., Crohn's disease (C...
Complex human diseases commonly differ in their phenotypic characteristics, e. g., Crohn's disease (...
Complex human diseases commonly differ in their phenotypic characteristics, e.g., Crohn's disease (C...
BACKGROUND & AIMS: Clinical presentation at diagnosis and disease course of Crohn's disease (CD) are...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
mutations, efforts in trying to link CD genetics to clinical subphenotypes have not been very succe...
Background: Crohn's Disease (CD) has a heterogeneous presentation, and is typically classified accor...
Background Crohn's Disease (CD) has a heterogeneous presentation, and is typically classified accor...
Complex human diseases commonly differ in their phenotypic characteristics, e.g., Crohn's disease (C...
Complex human diseases commonly differ in their phenotypic characteristics, e. g., Crohn's disease (...
Complex human diseases commonly differ in their phenotypic characteristics, e.g., Crohn's disease (C...
BACKGROUND & AIMS: Clinical presentation at diagnosis and disease course of Crohn's disease (CD) are...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...
Background & Aims: Crohn's disease is a common inflammatory disorder of the gut characterized by...