Intravaginal Practices, Bacterial Vaginosis, and HIV Infection in Women: Individual Participant Data Meta-analysis
- Low Nicola
- Chersich Matthew F.
- Schmidlin Kurt
- Egger Matthias
- Francis Suzanna C.
- H. H. M. van de Wijgert Janneke
- Hayes Richard J.
- Baeten Jared M.
- Brown Joelle
- Delany-Moretlwe Sinead
- Kaul Rupert
- McGrath Nuala
- Morrison Charles
- Myer Landon
- Temmerman Marleen
- van der Straten Ariane
- Watson-Jones Deborah
- Zwahlen Marcel
- Martin Hilber Adriane
DOIAbstract
Identifying modifiable factors that increase women's vulnerability to HIV is a critical step in developing effective female-initiated prevention interventions. The primary objective of this study was to pool individual participant data from prospective longitudinal studies to investigate the association between intravaginal practices and acquisition of HIV infection among women in sub-Saharan Africa. Secondary objectives were to investigate associations between intravaginal practices and disrupted vaginal flora; and between disrupted vaginal flora and HIV acquisition.<0.001), respectively.This study provides evidence to suggest that some intravaginal practices increase the risk of HIV acquisition but a direct causal pathway linking intravag...
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