Genetic Variation of the Fc Gamma Receptor 3B Gene and Association with Rheumatoid Arthritis
- Marques Rute B.
- Thabet Mohamed M.
- White Stefan J.
- Houwing-Duistermaat Jeanine J.
- Bakker Aleida M.
- Hendriks Gert-Jan
- Zhernakova Alexandra
- Huizinga Tom W.
- van der Helm-van Mil Annette H.
- Toes Rene E.
DOIAbstract
gene and its potential association with the autoimmune disease rheumatoid arthritis (RA). promoter region revealed an insertion/deletion (indel) that explained the disparate CNV results of MLPA probe#1. Finally, a non-significant trend was found between the novel -256A>TG indel and RA (40.7% in healthy controls versus 35.9% in RA patients; P = 0.08). CNV, the possible protective effect of the -256A>TG indel polymorphism must be addressed in larger studies
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