T Cells Are Associated with Subclinical Atherosclerosis: The Multi-Ethnic Study of Atherosclerosis
- Olson Nels C.
- Doyle Margaret F.
- Jenny Nancy Swords
- Huber Sally A.
- Psaty Bruce M.
- Kronmal Richard A.
- Tracy Russell P.
DOIAbstract
memory cells and lower proportions of naive cells, would be associated with subclinical atherosclerosis. titers were strongly associated with higher memory and lower naive cells (all p-values <0.05). Higher memory cells were associated with coronary artery calcification (CAC) level in the overall population [β-Coefficient (95% confidence interval (CI)) = 0.20 (0.03, 0.37)]. Memory and naive (inversely) cells were associated with common carotid artery intimal media thickness (CC IMT) in European-Americans [memory: β = 0.02 (0.006, 0.04); naive: β = −0.02 (−0.004, −0.03)]. T cells, and with innate immunity (inflammation), in atherosclerosis. These data are also consistent with the hypothesis that immunosenescence accelerates chronic diseas...
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