Impact of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on Cortical Thickness and Voxel-Based Morphometry in Healthy Chinese Young Adults

Yang Xuejuan
Liu Peng
Sun Jinbo
Wang Guihong
Zeng Fang
Yuan Kai
Liu Jixin
Dong Minghao
von Deneen Karen M.
Qin Wei
Tian Jie

Open link

Publication date

June 2012

DOI

10.1371/journal.pone.0037777

Publisher

Public Library of Science

Abstract

Following voxel-based morphometry (VBM), brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been shown to affect human brain morphology in Caucasians. However, little is known about the specific role of the Met/Met genotype on brain structure. Moreover, the relationship between BDNF Val66Met polymorphism and Chinese brain morphology has not been studied.<0.05). Areas with less GM in the Val/Met group were included in the Met/Met group. VBM differences in Met carriers were only found in the middle cingulate cortex.The current results indicated a unique pattern of brain morphologic differences caused by BDNF (rs6265) in young Chinese adults, in which the Met/Met genotype markedly affected the frontal, temporal, cingul...