Expression of Erk5 in Early Stage Breast Cancer and Association with Disease Free Survival Identifies this Kinase as a Potential Therapeutic Target

. Here we have investigated the expression and prognostic value of Erk5 in human breast cancer.), were used to investigate the influence of Erk5 on drugs used in the clinic to treat breast tumours. We found that inhibition of Erk5 decreased cancer cell proliferation and also sensitized these cells to the action of anti-HER2 therapies.Overexpression of Erk5 is an independent predictor of disease-free survival in breast cancer, and may represent a future therapeutic target