Insights into Pancreatic Cancer Etiology from Pathway Analysis of Genome-Wide Association Study Data
- Wei Peng
- Tang Hongwei
- Li Donghui
DOIAbstract
Pancreatic cancer is the fourth leading cause of cancer death in the U.S. and the etiology of this highly lethal disease has not been well defined. To identify genetic susceptibility factors for pancreatic cancer, we conducted pathway analysis of genome-wide association study (GWAS) data in 3,141 pancreatic cancer patients and 3,367 controls with European ancestry.<0.01) using the Database for Annotation, Visualization, and Integrated Discovery (DAVID). Functional enrichment analysis using DAVID consistently found the G protein-coupled receptor signaling pathway (including both neuroactive ligand-receptor interaction and olfactory transduction pathways) to be the most significant pathway for pancreatic cancer risk in this study population.T...
Add to ORKG