Breast Cancer Anti-Estrogen Resistance 4 (BCAR4) Drives Proliferation of IPH-926 lobular Carcinoma Cells
- van Agthoven Ton
- Dorssers Lambert C. J.
- Lehmann Ulrich
- Kreipe Hans
- Looijenga Leendert H. J.
- Christgen Matthias
DOIAbstract
in human breast cancer. mRNA expression was evaluated by (q)RT-PCR in a panel of human normal tissues, primary breast cancers and cell lines. A new antibody raised against C78-I97 of the putative BCAR4 protein and used for western blot and immunoprecipitation assays. Furthermore, siRNA-mediated gene silencing was implemented to study the function of BCAR4 and its downstream targets ERBB2/3. acts in an ERBB2/3-dependent manner.-driven tumor cell growth, a clinical relevant observation
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