Vitamin D Receptor Gene and Aggrecan Gene Polymorphisms and the Risk of Intervertebral Disc Degeneration — A Meta-Analysis

) polymorphisms and the risk of intervertebral disc degeneration (IDD), but produced conflicting results.we performed a meta-analysis to address a more accurate estimation of the associations between the above gene polymorphisms and the risk of IDD.. Publication bias was estimated using Begg's funnel plots and Egger's regression test. >23: OR = 1.955, 95%CI 1.41–2.703). Subgroup analysis confirmed the above results. After excluding studies deviated from Hardy-Weinberg equilibrium (HWE) in controls, no other studies were found to significantly influence the pooled effects in each genetic model. No potential publication bias was detected.) gene polymorphisms were not significantly associated with the risk of IDD. Since potential confounders could not be ruled out completely, further studies are needed to confirm these results