One-Carbon Metabolism Pathway Gene Variants and Risk of Clear Cell Renal Cell Carcinoma in a Chinese Population
- Zhang Lei
- Meng Xiaoxin
- Ju Xiaobing
- Cai Hongzhou
- Li Pu
- Cao Qiang
- Shao Pengfei
- Qin Chao
- Yin Changjun
DOIAbstract
One-carbon metabolism is the basement of nucleotide synthesis and the methylation of DNA linked to cancer risk. Variations in one-carbon metabolism genes are reported to affect the risk of many cancers, including renal cancer, but little knowledge about this mechanism is known in Chinese population.) were genotyped in 859 clear cell renal cell carcinoma (ccRCC) patients and 1005 cancer-free controls by the Snapshot.<0.001, adjusted OR = 0.68, 95%CI = 0.53–0.88) had an increased ccRCC risk.Our results suggest that the polymorphisms of the one-carbon metabolism-related genes are associated with ccRCC risk in Chinese population. Future population-based prospective studies are required to confirm the results
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