Rapid Assessment of Malaria Transmission Using Age-Specific Sero-Conversion Rates

Stewart Laveta
Gosling Roly
Griffin Jamie
Gesase Samwel
Campo Joseph
Hashim Ramadan
Masika Paul
Mosha Jacklin
Bousema Teun
Shekalaghe Seif
Cook Jackie
Corran Patrick
Ghani Azra
Riley Eleanor M.
Drakeley Chris

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Publication date

June 2009

DOI

10.1371/journal.pone.0006083

Publisher

Public Library of Science

Abstract

Malaria transmission intensity is a crucial determinant of malarial disease burden and its measurement can help to define health priorities. Rapid, local estimates of transmission are required to focus resources better but current entomological and parasitological methods for estimating transmission intensity are limited in this respect. An alternative is determination of antimalarial antibody age-specific sero-prevalence to estimate sero-conversion rates (SCR), which have been shown to correlate with transmission intensity. This study evaluated SCR generated from samples collected from health facility attendees as a tool for a rapid assessment of malaria transmission intensity. = 0.91, p<0.001).SCRs generated from age-specific anti-malaria...