Suppressor T Cells Induced via An Immune-Privileged Site: Quantifying Suppressor T Cells Functionally

suppressor T cells to quantify the antigen-specific suppression of DTH by these suppressor T cells.Suppressor T cells were induced in the spleens of mice by the injection of antigen into the anterior chamber of an eye. Following this injection, the mice were immunized by the same antigen injected into the anterior chamber. Spleen cells recovered from these mice (AC-SPL cells) were titrated in an adoptive transfer assay to determine the number of AC-SPL cells required to effect a 50% reduction of antigen-induced swelling (Sw50) in the footpad of immunized mice challenged by antigen. AC-SPL cells. Immunizing the mice receiving intracameral antigen to the same antigen decreases the RSw50 of AC-SPL cells required to inhibit the expression of DTH. suppressor T cells are specifically amplified by antigen during an immune response