Peripheral Blood Monocyte Sirt1 Expression Is Reduced in Patients with Coronary Artery Disease
- Breitenstein Alexander
- Wyss Christophe A.
- Spescha Remo D.
- Franzeck Fabian C.
- Hof Danielle
- Riwanto Meliana
- Hasun Matthias
- Akhmedov Alexander
- von Eckardstein Arnold
- Maier Willibald
- Landmesser Ulf
- Lüscher Thomas F.
- Camici Giovanni G.
DOIAbstract
Inflammation plays a key role in atherosclerosis. Sirt1 regulates transcription factors involved in inflammatory processes and blunts atherosclerosis in mice. However, its role in humans remains to be defined. This study was therefore designed to investigate the role of Sirt1 in the development of atherosclerosis.<0.001).Monocytic Sirt1 expression is reduced in patients with stable CAD and ACS. Experiments on THP-1 monocytes suggest that this effect is HDL-dependent and is mediated by a reduced activity of HDL-associated enzyme PON1
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