Regulatory T Cells and Promote the Development of Colorectal Cancer via Enhancing CCL20 Production in Mice

regulatory T (Treg)-cells dominantly infiltrate CRC. However, the underlying molecular mechanism in which TAMs may contribute to the trafficking of Treg-cells to the tumor mass remains unknown.. Injection of recombinant mouse CCL20 into tumor sites promoted its development with a marked recruitment of Treg-cells in the graft CRC model. Conditional macrophage ablation decreased CCL20 levels, blocked Treg-cell recruitment and inhibited tumor growth in CD11b-DTR mice grafted with CMT93. Treg-cells to tumor mass and promote its development via enhancing the production of CCL20 in a CRC mouse model