Humanized Mouse Model

Optimisation of the model is much needed for the study of new anti-malarial drugs, drug combinations, and candidate vaccines. instead of the intraperitoneal route (IP), by testing various immunosuppressive drugs that might help to control innate mouse defences, and by exploring the potential benefits of using immunodeficient mice with additional genetic defects, such as those with IL-2Rγ deficiency (NSG mice). strains without preliminary adaptation. However, results show that a major IL-12p70 inflammatory response remains prevalent.The combination of the NSG mouse, clodronate loaded liposomes, and IV delivery of huRBC has produced a reliable and more relevant model that better meets the needs of Malaria research