Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of several cancers including medulloblastoma, basal cell, small cell lung, pancreatic, prostate and ovarian. This investigation was designed to determine if inhibition of this pathway could inhibit serous ovarian cancer growth. pre-clinical model of serous ovarian cancer to characterize the anti-tumor activity of Hh pathway inhibitors cyclopamine and a clinically applicable derivative, IPI-926. Primary human serous ovarian tumor tissue was used to generate tumor xenografts in mice that were subsequently treated with cyclopamine or IPI-926. transcript levels and worsened survival.IPI-926 treatment inhibits serous tumor growth suggesting the Hh signalin...
The Hedgehog pathway is essential for embryonic development but also for tissue and organ homeostasi...
Hedgehog signalling pathway has not only a critical role in cell proliferation, differentiation and ...
The hedgehog pathway has been implicated in the tumorigenesis, tumor progression, and metastasis of ...
Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of severa...
Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of severa...
Tara L Lin1, William Matsui21Division of Hematology/Oncology, Department of Internal Medicine, Unive...
Abstract The hedgehog (Hh) signaling pathway regulates many processes of development and tissue home...
Abstract: Despite advances in surgical and chemotherapeutic treatment options, less than 50 % of pat...
The Hedgehog (Hh) signalling pathway plays a pivotal role in the spatial and temporal regulation of ...
Hedgehog (HH)-GLI signaling is a developmental patterning pathway used by many tumors for bulk proli...
The full spectrum of developmental potential includes normal as well as abnormal and disease states....
D ow nloaded from Aberrant activation of Hedgehog pathway has been implicated in the development of ...
The Hedgehog (Hh) signalling pathway plays a pivotal role in the spatial and temporal regulation of ...
Hedgehog signaling is a key regulator of development and stem cell fate and its aberrant activation ...
Hedgehog (HH)-GLI signaling is a developmental patterning pathway used by many tumors for bulk proli...
The Hedgehog pathway is essential for embryonic development but also for tissue and organ homeostasi...
Hedgehog signalling pathway has not only a critical role in cell proliferation, differentiation and ...
The hedgehog pathway has been implicated in the tumorigenesis, tumor progression, and metastasis of ...
Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of severa...
Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of severa...
Tara L Lin1, William Matsui21Division of Hematology/Oncology, Department of Internal Medicine, Unive...
Abstract The hedgehog (Hh) signaling pathway regulates many processes of development and tissue home...
Abstract: Despite advances in surgical and chemotherapeutic treatment options, less than 50 % of pat...
The Hedgehog (Hh) signalling pathway plays a pivotal role in the spatial and temporal regulation of ...
Hedgehog (HH)-GLI signaling is a developmental patterning pathway used by many tumors for bulk proli...
The full spectrum of developmental potential includes normal as well as abnormal and disease states....
D ow nloaded from Aberrant activation of Hedgehog pathway has been implicated in the development of ...
The Hedgehog (Hh) signalling pathway plays a pivotal role in the spatial and temporal regulation of ...
Hedgehog signaling is a key regulator of development and stem cell fate and its aberrant activation ...
Hedgehog (HH)-GLI signaling is a developmental patterning pathway used by many tumors for bulk proli...
The Hedgehog pathway is essential for embryonic development but also for tissue and organ homeostasi...
Hedgehog signalling pathway has not only a critical role in cell proliferation, differentiation and ...
The hedgehog pathway has been implicated in the tumorigenesis, tumor progression, and metastasis of ...