Transcriptome Analysis Describing New Immunity and Defense Genes in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis Patients
- Teixeira Vitor Hugo
- Olaso Robert
- Martin-Magniette Marie-Laure
- Lasbleiz Sandra
- Jacq Laurent
- Oliveira Catarina Resende
- Hilliquin Pascal
- Gut Ivo
- Cornelis François
- Petit-Teixeira Elisabeth
DOIAbstract
Large-scale gene expression profiling of peripheral blood mononuclear cells from Rheumatoid Arthritis (RA) patients could provide a molecular description that reflects the contribution of diverse cellular responses associated with this disease. The aim of our study was to identify peripheral blood gene expression profiles for RA patients, using Illumina technology, to gain insights into RA molecular mechanisms. values were adjusted to control the False Discovery Rate (FDR<5%). Genes differentially expressed at significant level between patients and controls were analyzed using Gene Ontology (GO) in the PANTHER database to identify biological processes. A differentially expression of 339 Reference Sequence genes (238 down-regulated and 101 u...
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