Manganese enhancement in non-CNS organs
- Lee, L.W.
- So, P.W.
- Price, A.N.
- Parkinson, J.R.C.
- Larkman, D.J.
- Halliday, J.
- Poucher, S.M.
- Pugh, J.A.T.
- Cox, A.G.
- McLeod, C.W.
- Bell, J.D.
- Lee, L.W.
- So, P.W.
- Price, A.N.
- Parkinson, J.R.C.
- Larkman, D.J.
- Halliday, J.
- Poucher, S.M.
- Pugh, J.A.T.
- Cox, A.G.
- McLeod, C.W.
- Bell, J.D.
DOIAbstract
Manganese-enhanced magnetic resonance imaging (MEMRI) is a novel imaging technique capable of monitoring calcium influx, in vivo. Manganese (Mn2+) ions, similar to calcium ions (Ca2+), are taken up by activated cells where their paramagnetic properties afford signal enhancement in T1-weighted MRI methodologies. In this study we have assessed Mn2+ distribution in mice using magnetization-prepared rapid gradient echo (MP-RAGE) based MRI, by measuring changes in T1–effective relaxation times (T1-eff), effective R1-relaxation rates (R1-eff) and signal intensity (SI) profiles over time. The manganese concentration in the tissue was also determined using inductively coupled plasma atomic emission spectrometry (ICP-AES). Our results show a strong ...
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