The pharmacokinetics and tissue distribution of Gentiopicroside (GPS), one of the major active components of the Gentiana species of medicinal plants, was studied following oral and intravenous administration in mice. The distribution of GPS in mice after oral and intravenous doses could be fitted to a two-compartments open model. The serum half-life of GPS was 6.1 h and 2.8 h for intravenous and oral administration, respectively. The Tmax of GPS after oral administration was 0.50 h, and the bioavailability was 39.6%. The AUC following intravenous administration was kidney >serum >liver >spleen >lung >thymus >fat >heart >muscle >stomach ¡ntestinal gradient in individual tissues >brain. The MRT gradient was muscle >serum >lung >spleen >lung...
PGG–PTX is a water-soluble formulation of paclitaxel (PTX), made by conjugating PTX to poly(l-γ-glut...
The aim of this study was to obtain pharmacokinetic data for the anxiolytic compound galphimine-A (G...
<p>The Pharmacokinetic Parameters of LPS in Normal Mice and Azithromycin-Treating Mice.</p
The pharmacokinetics in rats of gentiopicroside (GPS) from orally administered decoctions ofRadix Ge...
The pharmacokinetics and bioavailability of gentiopicroside (GPS), an active component of the Gentia...
Both geniposide (Ge) and borneol (Bo) are bioactive substances derived from traditional Chinese medi...
A sensitive and efficient liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was deve...
The aim of the study was to characterize the preclinical pharmacokinetics and comparative pharmacoki...
This study was to analyze the distribution of liposomal-methylprednisolone palmitate (L-MPLP) a...
Item does not contain fulltextTo be able to evaluate new radiopharmaceuticals and optimize diagnosti...
<p>Plasma, skin, and intestine samples were collected from the mice orally administered 30 mg/kg Com...
This study investigated the pharmacokinetics and tissue distribution of enavogliflozin, a novel sodi...
Microdialysis, a sampling method for pharmacokinetics–pharmacodynamics (PK–PD) modeling in preclinic...
Pharmacokinetics, tissue distribution and excretion of vitexin (VIT) were studied after intravenous ...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
PGG–PTX is a water-soluble formulation of paclitaxel (PTX), made by conjugating PTX to poly(l-γ-glut...
The aim of this study was to obtain pharmacokinetic data for the anxiolytic compound galphimine-A (G...
<p>The Pharmacokinetic Parameters of LPS in Normal Mice and Azithromycin-Treating Mice.</p
The pharmacokinetics in rats of gentiopicroside (GPS) from orally administered decoctions ofRadix Ge...
The pharmacokinetics and bioavailability of gentiopicroside (GPS), an active component of the Gentia...
Both geniposide (Ge) and borneol (Bo) are bioactive substances derived from traditional Chinese medi...
A sensitive and efficient liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was deve...
The aim of the study was to characterize the preclinical pharmacokinetics and comparative pharmacoki...
This study was to analyze the distribution of liposomal-methylprednisolone palmitate (L-MPLP) a...
Item does not contain fulltextTo be able to evaluate new radiopharmaceuticals and optimize diagnosti...
<p>Plasma, skin, and intestine samples were collected from the mice orally administered 30 mg/kg Com...
This study investigated the pharmacokinetics and tissue distribution of enavogliflozin, a novel sodi...
Microdialysis, a sampling method for pharmacokinetics–pharmacodynamics (PK–PD) modeling in preclinic...
Pharmacokinetics, tissue distribution and excretion of vitexin (VIT) were studied after intravenous ...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
PGG–PTX is a water-soluble formulation of paclitaxel (PTX), made by conjugating PTX to poly(l-γ-glut...
The aim of this study was to obtain pharmacokinetic data for the anxiolytic compound galphimine-A (G...
<p>The Pharmacokinetic Parameters of LPS in Normal Mice and Azithromycin-Treating Mice.</p