Deficiency of complement factor C5 reduces early mortality but does not prevent organ damage in an animal model of multiple organ dysfunction syndrome

Complement system specifically C5a receptor, inflammation and hypertrophic cardiomyopathy (HCM) in cats

Mohd Nazirul Mubin bin Puteh Ahmad

The complement cascade is a unique sequence of molecular events occurring within the vascular system...

Decay-Accelerating Factor Creates an Organ-Protective Phenotype after Hemorrhage in Conscious Rats

Milomir O. Simovic
Michael J. Falabella
Tuan D. Le
Jurandir J. DalleLucca
Yansong Li

November 2022

Preclinical and clinical studies have shown that traumatic hemorrhage (TH) induces early complement ...

Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury:Inhibition of late apoptosis and inflammation

De Vries, B
Matthijsen, RA
Wolfs, TGAM
Van Bijnen, AAJHM
Heeringa, P
Buurman, WA

February 2003

Background Complement has been implicated in the pathophysiology of renal ischemia-reperfusion (I/R)...

A novel role of complement: mice deficient in the fifth componenet of complement (C5) exhibit impaired liver regeneration.

Mastellos, D
Papadimitriou, J. C
Franchini, Silvia
Tsonis, P. A
Lambris, J. D.

January 2001

Components of innate immunity have recently been implicated in the regulation of developmental proce...

A novel role for the fifth component of complement (C5) in cardiac physiology.

Alaka Mullick
Jessy Tremblay
Zully Leon
Philippe Gros

We have previously demonstrated that C5-deficient A/J and recombinant congenic BcA17 mice suffer fro...

Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing

Langereis, J.D.
Molen, R.G. van der
Kat Angelino, C.M. de
Henriet, S.S.
Jonge, M.I. de
Joosten, I.
Simons, A.
Schuurs-Hoeijmakers, J.H.M.
Deuren, M. van
Aerde, K.J. van
Flier, M. van der

January 2021

Contains fulltext : 233465.pdf (Publisher’s version ) (Open Access

An inhibitor of complement C5 provides structural insights into activation

Reichhardt, Martin P.
Johnson, Steven
Tang, Terence
Morgan, Thomas
Tebeka, Nchimunya
Popitsch, Niko
Jore, M.M.
Lea, Susan M.

January 2020

Contains fulltext : 216674.pdf (Publisher’s version ) (Open Access

Complement C5

Chandrasekhar, Anjana
Dinasarapu, Ashok Reddy
Isenman, David E.
Subramaniam, Shankar

January 2012

Complement C5 is a 189 kDa protein synthesized in liver as a single-chain precursor molecule. The pr...

In vivo characterisation and therapeutic efficacy of a C5-specific inhibitor [Abstract]

Hepburn, Natalie J.
Williams, Anwen Sian
Chamberlain, Jayne C.
Hamer, Joseph
Nunn, M. A.
Morgan, Bryan Paul
Harris, Claire Louise

January 2007

The involvement of complement in the perpetuation and exacerbation of many inflammatory diseases has...

Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury: inhibition of late apoptosis and inflammation

de Vries, B.
Matthijsen, R.A.
Wolfs, T.G.A.M.
van Bijnen, A.A.
Heeringa, P.
Buurman, W.A.

January 2003

Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury: inhibition of...

Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function

Pischke, Søren Erik
Gustavsen, Alice
Orrem, HL
Egge, Kjetil Hagene
Courivaud, Fredric A A
Fontenelle, Hugues
Despont, Alain
Bongoni, Anjan K.
Rieben, Robert
Tønnessen, Tor Inge
Nunn, Miles A.
Scott, Helge
Skulstad, Helge
Barratt-Due, Andreas
Mollnes, Tom Eirik

January 2017

Inhibition of complement factor 5 (C5) reduced myocardial infarction in animal studies, while no ben...

Skipping of exon 30 in C5 gene results in complete human C5 deficiency and demonstrates the importance of C5d and CUB domains for stability

AGUILAR-RAMIREZ, P.
REIS, E. S.
FLORIDO, M. P. C.
BARBOSA, A. S.
FARAH, C. S.
COSTA-CARVALHO, B. T.
ISAAC, L.

January 2009

The deficiency of complement C5 is rare and frequently associated with severe and recurrent infectio...

Complement 5a Receptor deficiency does not influence adverse cardiac remodeling after pressure-overload in mice

De Haan, Judith J.
Bosch, Lena
Borgman, Anouska
Bastemeijer, Marissa
Brans, Maike A.D.
Van De Weg, Sander M.
De Kleijn, Dominique P.V.
Sluijter, Joost P.G.
El Azzouzi, Hamid
De Jager, Saskia C.A.

December 2017

Hypertension is one of the most common risk factors for the development heart failure in the general...

Inhibition of C5a-induced inflammation with preserved C5b-9-mediated bactericidal activity in a human whole blood model of meningococcal sepsis

Sprong, T.
Brandtzaeg, P.
Fung, M.
Pharo, A.M.
Hoiby, E.A.
Michaelsen, T.E.
Aase, A.
Meer, J.W.M. van der
Deuren, M. van
Molines, T.E.

January 2003

Contains fulltext : 19740.pdf (publisher's version ) (Closed access

Complement component C5a mediates hemorrhage-induced intestinal damage

Fleming, Sherry D.
Phillips, Lauren M.
Lambris, John D.
Tsokos, George C.

January 2008

Background: Complement has been implicated in the pathogenesis of intestinal damage and inflammation...

Complement system specifically C5a receptor, inflammation and hypertrophic cardiomyopathy (HCM) in cats

Mohd Nazirul Mubin bin Puteh Ahmad

The complement cascade is a unique sequence of molecular events occurring within the vascular system...

Decay-Accelerating Factor Creates an Organ-Protective Phenotype after Hemorrhage in Conscious Rats

Milomir O. Simovic
Michael J. Falabella
Tuan D. Le
Jurandir J. DalleLucca
Yansong Li

November 2022

Preclinical and clinical studies have shown that traumatic hemorrhage (TH) induces early complement ...

Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury:Inhibition of late apoptosis and inflammation

De Vries, B
Matthijsen, RA
Wolfs, TGAM
Van Bijnen, AAJHM
Heeringa, P
Buurman, WA

February 2003

Background Complement has been implicated in the pathophysiology of renal ischemia-reperfusion (I/R)...

A novel role of complement: mice deficient in the fifth componenet of complement (C5) exhibit impaired liver regeneration.

Mastellos, D
Papadimitriou, J. C
Franchini, Silvia
Tsonis, P. A
Lambris, J. D.

January 2001

Components of innate immunity have recently been implicated in the regulation of developmental proce...

A novel role for the fifth component of complement (C5) in cardiac physiology.

Alaka Mullick
Jessy Tremblay
Zully Leon
Philippe Gros

We have previously demonstrated that C5-deficient A/J and recombinant congenic BcA17 mice suffer fro...

Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing

Langereis, J.D.
Molen, R.G. van der
Kat Angelino, C.M. de
Henriet, S.S.
Jonge, M.I. de
Joosten, I.
Simons, A.
Schuurs-Hoeijmakers, J.H.M.
Deuren, M. van
Aerde, K.J. van
Flier, M. van der

January 2021

Contains fulltext : 233465.pdf (Publisher’s version ) (Open Access

An inhibitor of complement C5 provides structural insights into activation

Reichhardt, Martin P.
Johnson, Steven
Tang, Terence
Morgan, Thomas
Tebeka, Nchimunya
Popitsch, Niko
Jore, M.M.
Lea, Susan M.

January 2020

Contains fulltext : 216674.pdf (Publisher’s version ) (Open Access

Complement C5

Chandrasekhar, Anjana
Dinasarapu, Ashok Reddy
Isenman, David E.
Subramaniam, Shankar

January 2012

Complement C5 is a 189 kDa protein synthesized in liver as a single-chain precursor molecule. The pr...

In vivo characterisation and therapeutic efficacy of a C5-specific inhibitor [Abstract]

Hepburn, Natalie J.
Williams, Anwen Sian
Chamberlain, Jayne C.
Hamer, Joseph
Nunn, M. A.
Morgan, Bryan Paul
Harris, Claire Louise

January 2007

The involvement of complement in the perpetuation and exacerbation of many inflammatory diseases has...

Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury: inhibition of late apoptosis and inflammation

de Vries, B.
Matthijsen, R.A.
Wolfs, T.G.A.M.
van Bijnen, A.A.
Heeringa, P.
Buurman, W.A.

January 2003

Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury: inhibition of...

Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function

Pischke, Søren Erik
Gustavsen, Alice
Orrem, HL
Egge, Kjetil Hagene
Courivaud, Fredric A A
Fontenelle, Hugues
Despont, Alain
Bongoni, Anjan K.
Rieben, Robert
Tønnessen, Tor Inge
Nunn, Miles A.
Scott, Helge
Skulstad, Helge
Barratt-Due, Andreas
Mollnes, Tom Eirik

January 2017

Inhibition of complement factor 5 (C5) reduced myocardial infarction in animal studies, while no ben...

Skipping of exon 30 in C5 gene results in complete human C5 deficiency and demonstrates the importance of C5d and CUB domains for stability

AGUILAR-RAMIREZ, P.
REIS, E. S.
FLORIDO, M. P. C.
BARBOSA, A. S.
FARAH, C. S.
COSTA-CARVALHO, B. T.
ISAAC, L.

January 2009

The deficiency of complement C5 is rare and frequently associated with severe and recurrent infectio...

Complement 5a Receptor deficiency does not influence adverse cardiac remodeling after pressure-overload in mice

De Haan, Judith J.
Bosch, Lena
Borgman, Anouska
Bastemeijer, Marissa
Brans, Maike A.D.
Van De Weg, Sander M.
De Kleijn, Dominique P.V.
Sluijter, Joost P.G.
El Azzouzi, Hamid
De Jager, Saskia C.A.

December 2017

Hypertension is one of the most common risk factors for the development heart failure in the general...

Inhibition of C5a-induced inflammation with preserved C5b-9-mediated bactericidal activity in a human whole blood model of meningococcal sepsis

Sprong, T.
Brandtzaeg, P.
Fung, M.
Pharo, A.M.
Hoiby, E.A.
Michaelsen, T.E.
Aase, A.
Meer, J.W.M. van der
Deuren, M. van
Molines, T.E.

January 2003

Contains fulltext : 19740.pdf (publisher's version ) (Closed access

Complement component C5a mediates hemorrhage-induced intestinal damage

Fleming, Sherry D.
Phillips, Lauren M.
Lambris, John D.
Tsokos, George C.

January 2008

Background: Complement has been implicated in the pathogenesis of intestinal damage and inflammation...

Complement system specifically C5a receptor, inflammation and hypertrophic cardiomyopathy (HCM) in cats

Mohd Nazirul Mubin bin Puteh Ahmad

The complement cascade is a unique sequence of molecular events occurring within the vascular system...

Decay-Accelerating Factor Creates an Organ-Protective Phenotype after Hemorrhage in Conscious Rats

Milomir O. Simovic
Michael J. Falabella
Tuan D. Le
Jurandir J. DalleLucca
Yansong Li

November 2022

Preclinical and clinical studies have shown that traumatic hemorrhage (TH) induces early complement ...

Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury:Inhibition of late apoptosis and inflammation

De Vries, B
Matthijsen, RA
Wolfs, TGAM
Van Bijnen, AAJHM
Heeringa, P
Buurman, WA

February 2003

Background Complement has been implicated in the pathophysiology of renal ischemia-reperfusion (I/R)...

Deficiency of complement factor C5 reduces early mortality but does not prevent organ damage in an animal model of multiple organ dysfunction syndrome

Abstract

Extracted data

Deficiency of complement factor C5 reduces early mortality but does not prevent organ damage in an animal model of multiple organ dysfunction syndrome

Abstract

Extracted data

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