In vivo and in vitro hepatic 31P magnetic resonance spectroscopy and electron microscopy of the cirrhotic liver
- Taylor-Robinson, S.D.
- Sargentoni, J.
- Bell, J.D.
- Saeed, N.
- Changani, K.K.
- Davidson, B.R.
- Rolles, K.
- Burroughs, A.K.
- Hodgson, H.J.F.
- Foster, C.S.
- Cox, I.J.
- Taylor-Robinson, S.D.
- Sargentoni, J.
- Bell, J.D.
- Saeed, N.
- Changani, K.K.
- Davidson, B.R.
- Rolles, K.
- Burroughs, A.K.
- Hodgson, H.J.F.
- Foster, C.S.
- Cox, I.J.
DOIAbstract
In vivo 31P magnetic resonance spectroscopy (MRS) provides direct biochemical information on hepatic metabolic processes. To assess in vivo changes in hepatic 31P MRS in liver transplant candidates, we studied 31 patients with cirrhosis of varying aetiology; 14 with compensated cirrhosis (Pugh's score <7) and 17 with decompensated cirrhosis (Pugh's score <8). Underlying cellular abnormalities were characterised using in vitro31P MRS and electron microscopy. In vitro spectra were obtained from liver extracts, freeze-clamped at recipient hepatectomy, from all subjects. Electron microscopy of liver tissue was also performed in 17 cases. Relative to nucleotide triphosphates, elevations in phosphomonoesters and reductions in phosphodiesters were...
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