Airway Microbiome; Allergy, Asthma

The rate at which the prevalence of allergy keeps rising globally poses a threat to health and economic development.Various parts of the immune system are involved in this process and some delineated genetic and environmental factors seem to contribute to the development of allergy. The gut microbiome contains the largest collection of bacteria in the human body that interacts with the immune system, subsequently playing a role in contribution to immunogenic tolerance.Altered diversity of the gut microbiome during infancy as well as colonization with specific pathogenic and non-pathogenic bacteria has been linked with an elevated risk for allergy and asthma.Diversity within the airway microbiome reflects either a diseased or healthy state. Interesting differences have been found between microbial compositions in the airways of healthy and diseased people, such as patients with allergic asthma.Relationships between the disease severity, co-morbidities, control status and use of medication suggest that a number of interactions between the airway microbiome, host immunity and potential exposures likely have roles in the type and degree of airway inflammation and could possibly clarify some of the heterogeneity expressed in some allergic diseases like asthma.egységes, osztatlanáltalános orvosango