Levosimendan application in modern day medicine

Acute heart failure is becoming a central epidemiological concern in the modern day society with relatively high morbidity and mortality rates. The current therapeutic approach relies on different strategies depending on the patients’ course of illness and personal needs. Patients with hypotension, hypo perfusion or shock benefit from ionotrpic support, while patients with systemic or pulmonary congestion will benefit from diuretics and vasodilators. Traditional inotropic agents load cardiomyocites with Ca2+ causing increased oxygen consumption and increased risk of arrhythmias, a side effect that may be avoided by using sarcomere targeted agents which will activate contraction by sensitizing cardiac myofilaments to Ca2+ or by direct activation of cardiac myosin. In this paper I will be focusing on sarcomere targeting drugs, their mechanism of action and its benefits to a variety of cardiology related conditions.egységes, osztatlanáltalános orvosango