Toxicity and carcinogenicity of the fusanum monilzforine metabolite, fumonisin B1, in rats.
- Gelderblom, Wentzel
- Kriek, NPJ
- Marasas, WFO
- Thiel, PG
DOIAbstract
A semi-purified corn-based diet containing 50 mg/kg of pure (not <90%) fumonlsin B1 (FB1), isolated from culture material of Fusarusm monthforme strain MRC 826, was fed to a group of 25 rats over a period of 26 months. A control group of 25 rats received the same diet without FB1 Five rats from each group were killed at 6, 12, 20 and 26 months. The liver was the main target organ in the FB1-rats and the hepatic pathological changes were identical to those previously reported in rats fed culture material of F.moniliforme MRC 826. All FB1-treated rats that died or were killed from 18 months onwards suffered from a micro-and macronodular cirrhosis and had large expansile nodules of cholangiofibrosis at the hilus of the liver. Ten out of 15 FB1...
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