Fine-scale parameterizations based on shear and stratification are widely used to study the intensity and spatial distribution of turbulent diapycnal mixing in the ocean. Two well-known fine-scale parameterizations, Gregg-Henyey-Polzin (GHP) parameterization and MacKinnon-Gregg (MG) parameterization, are assessed with the full-depth microstructure data obtained in the North Pacific. The GHP parameterization commonly used in the open ocean succeeds in reproducing the dissipation rates over smooth topography but fails to predict the turbulence over rough topography. Failure of GHP parameterization over rough topography is attributed to the deviation of internal wave spectrum from the Garrett-Munk (GM) spectrum. The internal wave field over ro...