Mandibular prognathism is a facial skeletal malocclusion. Until now, the genetic mechanism has been unclear. The goal of this study was to identify candidate genes or genomic regions directly associated with mandibular prognathism development, by employing whole genome sequencing. A large Chinese family was recruited, composed of 9 affected and 12 unaffected individuals, and the inheritance pattern of this family tends to be autosomal dominant. A single-nucleotide missense mutation in the ADAMTS1 gene (c. 742I>T) was found to segregate in the family, given that the affected individuals must be heterozygous for the mutation. For mutation validation, we screened this candidate mutation and 15 tag single-nucleotide polymorphisms in the codi...
Previous linkage analysis of an Asian population proposed possible candidate genes for mandibular pr...
ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) are a family of multidomain ...
Introduction: Evidence suggests that several genes; including MYO1H, play an important role in the e...
Mandibular prognathism is a facial skeletal malocclusion. Until now, the genetic mechanism has been ...
Mandibular prognathism (MP) is a recognizable phenotype associated with dentoskeletal class III malo...
It is well known that genetic components play an important role in the etiology of mandibular progna...
BACKGROUND: It is well known that genetic components play an important role in the etiology of mandi...
Mandibular prognathism (MP) is the relationship of the mandible anteriorly positioned in relation to...
Mandibular prognathism typically shows familial aggregation. Various genetic models have been descri...
Background Mandibular prognathism (MP) is a craniofacial deformity resulting from the combined effec...
Objective: The results of a genome-wide scan suggested that chromosome locus 1p36 might be linked to...
Introduction: PAX9 (Paired box 9) gene is one of the genes which play significant role during cranio...
INTRODUCTION: Several candidate loci have been suggested as influencing mandibular prognathism (1p22...
Genetic basis of mandibular prognathism Mandibular prognathism is one of the craniofacial bone defec...
Introduction: Several candidate loci have been suggested as influencing mandibular prognathism (1p22...
Previous linkage analysis of an Asian population proposed possible candidate genes for mandibular pr...
ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) are a family of multidomain ...
Introduction: Evidence suggests that several genes; including MYO1H, play an important role in the e...
Mandibular prognathism is a facial skeletal malocclusion. Until now, the genetic mechanism has been ...
Mandibular prognathism (MP) is a recognizable phenotype associated with dentoskeletal class III malo...
It is well known that genetic components play an important role in the etiology of mandibular progna...
BACKGROUND: It is well known that genetic components play an important role in the etiology of mandi...
Mandibular prognathism (MP) is the relationship of the mandible anteriorly positioned in relation to...
Mandibular prognathism typically shows familial aggregation. Various genetic models have been descri...
Background Mandibular prognathism (MP) is a craniofacial deformity resulting from the combined effec...
Objective: The results of a genome-wide scan suggested that chromosome locus 1p36 might be linked to...
Introduction: PAX9 (Paired box 9) gene is one of the genes which play significant role during cranio...
INTRODUCTION: Several candidate loci have been suggested as influencing mandibular prognathism (1p22...
Genetic basis of mandibular prognathism Mandibular prognathism is one of the craniofacial bone defec...
Introduction: Several candidate loci have been suggested as influencing mandibular prognathism (1p22...
Previous linkage analysis of an Asian population proposed possible candidate genes for mandibular pr...
ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) are a family of multidomain ...
Introduction: Evidence suggests that several genes; including MYO1H, play an important role in the e...