Complementary regioselectivity in the synthesis of iminohydantoins: remarkable effect of amide substitution on the cyclization

Complementary regioselective synthesis of iminohydantoins from isocyanoacetamides controlled by the substituent on the amide group has been described. 4-Iminohydantoins were the major products when the starting materials were N-alkyl isocyanoamides, whereas 2-iminohydantoins were the major products with N-aryl isocyanoamides.Ministerio de Ciencia e Innovación, Spain (Project CTQ2009-12631- BQU), Junta de Castilla y León, Consejería de Educación y Cultura y Fondo Social Europeo (Projects BU023A09 and GR170)