Efficacy of a proprietary Trigonella foenum-graecum L. de-husked seed extract in reducing menopausal symptoms in otherwise healthy women: a double-blind, randomized, placebo-controlled study

Trigonella foenum-graecum seed extract has demonstrated hormone modulatory activity, providing biological plausibility for relieving menopausal symptoms. The study aimed to assess efficacy of a standardized T. foenum-graecum de-husked seed extract in reducing menopausal symptoms in healthy aging women. The study was a double-blind, randomized, placebo-controlled trial that recruited 115 women aged 40 to 65\ua0years of which 59 were allocated to active (n\ua0=\ua054 completed) and 56 to placebo (n\ua0=\ua050 completed). Active treatment was T. foenum-graecum de-husked seed extract, 600\ua0mg per day for 12\ua0weeks. Outcome measures included Menopause-Specific Quality of Life (MENQOL) questionnaire, frequency of hot flushes and night sweats and serum estradiol levels. There was a significant reduction in menopausal symptoms in the active group compared with placebo as assessed by total MENQOL score (p\ua