Microbiological parameters that influence the treatment outcomes of monodrug and multidrug-resistant tuberculosis

Magister Pharmaceuticae - MpharmPrevious studies have reported microbiological parameters such as HIV infection, resistance to anti-TB drugs such as fluoroquinolones, resistance to previous treatment with anti-TB drugsand extrapulmonary TB, causing poor treatment outcomes in patients with monodrug and multidrugresistant tuberculosis. However, little is known about the time to sputum culture conversion in HIV-positive patients infected with monodrug and multidrug-resistant tuberculosis in South Africa, and currently there is no information on the effects of inappropriate (i.e. low and high) anti-tuberculosis drug-dose on the time to sputum culture conversion in monodrug and multidrug-resistant TB patients. The aim of the study was to investigate whether or not there is a difference between the time to sputum culture conversion in drug-resistant tuberculosis patients with HIV, and those without HIV infection. It also aimed to find out whether inappropriate (i.e. low and high) anti-tuberculosis drug dose could affect the time to sputum culture conversion in drug-resistant TB patients. In addition, the influence of HIV infection (CD4 count and viral load), drug resistance type, impact of antiretroviral duration before TB treatment, the replacement of ofloxacin by moxifloxacin and DR-TB localization were assessed on drugresistant TB treatment outcomes