Various types of repetitive sequences are dysregulated in cancer. In Ewing sarcoma, the oncogenic fusion protein EWS-FLI1 induces chromatin features typical of active enhancers at GGAA microsatellite repeats, but the function of these sites has not been directly demonstrated. Here, by combining nascent transcription profiling with epigenome editing, we found that a subset of GGAA microsatellite repeats is transcriptionally active in Ewing sarcoma and that silencing individual repeats abolishes local nascent transcription and leads to markedly reduced expression of putative target genes. Epigenome silencing of these repeat sites does not affect gene expression in unrelated cells, can prevent the induction of gene expression by EWS-FLI1, and,...
Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphi...
SummaryTranscription factor fusion proteins can transform cells by inducing global changes of the tr...
Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from mesenchymal stem cells...
Various types of repetitive sequences are dysregulated in cancer. In Ewing sarcoma, the oncogenic fu...
Ewing sarcoma is the second most common form of pediatric bone cancer and is characterized by chromo...
SummaryThe aberrant transcription factor EWS-FLI1 drives Ewing sarcoma, but its molecular function i...
Numerous molecular abnormalities contribute to the genetic derangements involved in tumorigenesis. C...
Ewing sarcoma is a bone malignancy of children and young adults, frequently harboring the EWS/FLI ch...
<div><p>Ewing sarcoma is a bone malignancy of children and young adults, frequently harboring the EW...
The aberrant transcription factor EWS-FLI1 drives Ewing sarcoma, but its molecular function is not c...
International audienceDeciphering the ways in which somatic mutations and germline susceptibility va...
pre-printBackground: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly ...
Q2Q1Ewing sarcoma (ES) is a primary bone marrow tumor that very rarely develops in extra-osseous tis...
BACKGROUND: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understoo...
Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphi...
SummaryTranscription factor fusion proteins can transform cells by inducing global changes of the tr...
Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from mesenchymal stem cells...
Various types of repetitive sequences are dysregulated in cancer. In Ewing sarcoma, the oncogenic fu...
Ewing sarcoma is the second most common form of pediatric bone cancer and is characterized by chromo...
SummaryThe aberrant transcription factor EWS-FLI1 drives Ewing sarcoma, but its molecular function i...
Numerous molecular abnormalities contribute to the genetic derangements involved in tumorigenesis. C...
Ewing sarcoma is a bone malignancy of children and young adults, frequently harboring the EWS/FLI ch...
<div><p>Ewing sarcoma is a bone malignancy of children and young adults, frequently harboring the EW...
The aberrant transcription factor EWS-FLI1 drives Ewing sarcoma, but its molecular function is not c...
International audienceDeciphering the ways in which somatic mutations and germline susceptibility va...
pre-printBackground: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly ...
Q2Q1Ewing sarcoma (ES) is a primary bone marrow tumor that very rarely develops in extra-osseous tis...
BACKGROUND: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understoo...
Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphi...
SummaryTranscription factor fusion proteins can transform cells by inducing global changes of the tr...
Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from mesenchymal stem cells...