Hypermethylation of HOOK2 gene and its relation with Type 2 diabetes susceptibility in individuals with obesity
- Sandra Rodríguez-Rodero (4675789)
- Edelmiro Menéndez-Torre (4675795)
- Gustavo Fernández-Bayón (4675765)
- Paula Morales-Sánchez (4675777)
- Lourdes Sanz (4675783)
- Estrella Turienzo (4675771)
- Juan José González (1888069)
- Ceferino Martinez-Faedo (4675792)
- Lorena Suarez-Gutiérrez (4675762)
- Jessica Ares (4675786)
- Lucia Díaz-Naya (4675774)
- Alicia Martin-Nieto (4675780)
- Juan L. Fernández-Morera (4675759)
- Mario F. Fraga (74335)
- Elías Delgado-Álvarez (4675768)
Publication date
August 2018
DOIAbstract
<p>Failure in glucose response to insulin is a common pathology associated with obesity. In this study, we analyzed the genome wide DNA methylation profile of visceral adipose tissue samples in a population of individuals with obesity and assessed whether differential methylation profiles are associated with the presence of type 2 diabetes (T2D).</p> <p>More than 485,000 CpG genome sites from visceral adipose tissue samples from women with obesity undergoing gastric bypass (n=18), and classified as suffering from type 2 diabetes or not (no type 2 diabetes, NT2D), were analyzed using DNA methylation arrays.</p
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