Additional file 1: of Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

Molnár, Eszter
Rittler D
Baranyi, Marcell
Grusch M
Berger W
Döme, Balázs
Tóvári, József
Aigner C
Tímár, József
Garay, Tamás
Hegedűs, Balázs

May 2018

BACKGROUND: Currently, there are no available targeted therapy options for non-V600 BRAF mutated tum...

Additional file 3: of Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer

Murugan Kalimutho (6375365)
Debottam Sinha (6375368)
Deepak Mittal (4967743)
Sriganesh Srihari (3542939)
Devathri Nanayakkara (6375371)
Shagufta Shafique (759049)
Prahlad Raninga (6375374)
Purba Nag (6375377)
Kate Parsons (6375380)
Kum Khanna (3588107)

February 2019

Figure S2: (A) Hs578T cells were exposed to different concentrations of MEK1/2 inhibitor (AZD6244) a...

Additional file 2: of A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

Tonći Šuštić (6016781)
Sake van Wageningen (3583763)
Evert Bosdriesz (6016790)
Robert Reid (3433565)
John Dittmar (6016793)
Cor Lieftink (6016799)
Roderick Beijersbergen (6016805)
Lodewyk Wessels (66823)
Rodney Rothstein (17038)
René Bernards (82847)

November 2018

Figure S1. Genome-wide synthetic lethal screens with RAS1(V19) and RAS2(V19) identify overlapping se...

Additional file 2: of Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

Eszter Molnár (688832)
Dominika Rittler (5186183)
Marcell Baranyi (5186186)
Michael Grusch (470621)
Walter Berger (194987)
Balázs Döme (470625)
József Tóvári (168476)
Clemens Aigner (5186177)
József Tímár (5186180)
Tamás Garay (688831)
Balázs Hegedűs (470624)

May 2018

Figure S2. Analysis of cell cycle after treatment with selumetinib or sorafenib and combination. Cel...

Additional file 3: of Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Christiane Margue (378328)
Demetra Philippidou (378327)
Ines Kozar (5825252)
Giulia Cesi (387421)
Paul Felten (757793)
Dagmar Kulms (150425)
Elisabeth Letellier (844555)
Claude Haan (378330)
Stephanie Kreis (378326)

February 2019

Figure S1. Dose-response curves of selected kinase inhibitors in parental and BRAFi-resistant A375 c...

Additional file 4: of Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Christiane Margue (378328)
Demetra Philippidou (378327)
Ines Kozar (5825252)
Giulia Cesi (387421)
Paul Felten (757793)
Dagmar Kulms (150425)
Elisabeth Letellier (844555)
Claude Haan (378330)
Stephanie Kreis (378326)

February 2019

Figure S2. Dose-response curves of selected kinase inhibitors in parental and BRAFi-resistant IGR37 ...

Additional file 1: of Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models

Anais Del Curatolo (5495051)
Fabiana Conciatori (5495060)
Ursula Cesta Incani (5495054)
Chiara Bazzichetto (5495066)
Italia Falcone (5495063)
Vincenzo Corbo (242342)
Sabrina DâAgosto (5495069)
Adriana Eramo (129964)
Giovanni Sette (129952)
Isabella Sperduti (85365)
Teresa De Luca (1773619)
Mirko Marabese (399904)
Senji Shirasawa (268173)
Ruggero De Maria (129963)
Aldo Scarpa (242345)
Massimo Broggini (74308)
Donatella Del Bufalo (132771)
Francesco Cognetti (510876)
Michele Milella (725941)
Ludovica Ciuffreda (5495057)

July 2018

Supplementary Methods. Figure S1. RAF inhibition induces BRAF/CRAF heterodimerization in KRAS-mut co...

Additional file 1: Figure S1. of Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cells

Sebastian Halbach (3477770)
Zehan Hu (3477767)
Christine Gretzmeier (1874908)
Julia Ellermann (3477764)
Franziska Wöhrle (3477776)
Jörn Dengjel (147670)
Tilman Brummer (107550)

February 2016

(A/B) Ba/F3 vector cells and cells transformed with pBABE Bcr-Abl were exposed to the indicated inhi...

Additional file 3: Figure S2. of PLX8394, a new generation BRAF inhibitor, selectively inhibits BRAF in colonic adenocarcinoma cells and prevents paradoxical MAPK pathway activation

Candani Tutuka (4181644)
Miles Andrews (3763117)
John Mariadason (94966)
Paul Ioannidis (4181647)
Christopher Hudson (383417)
Jonathan Cebon (124236)
Andreas Behren (3460808)

June 2017

The effect of BRAF inhibitors vemurafenib and PLX8394 on BRAF wt / KRAS G13D cell line HCT 116. Cell...

Additional file 8: of Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Christiane Margue (378328)
Demetra Philippidou (378327)
Ines Kozar (5825252)
Giulia Cesi (387421)
Paul Felten (757793)
Dagmar Kulms (150425)
Elisabeth Letellier (844555)
Claude Haan (378330)
Stephanie Kreis (378326)

February 2019

Figure 6. Dose-response curves of selected kinase inhibitors in the presence or absence of BRAF inhi...

Additional file 1: of Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Christiane Margue (378328)
Demetra Philippidou (378327)
Ines Kozar (5825252)
Giulia Cesi (387421)
Paul Felten (757793)
Dagmar Kulms (150425)
Elisabeth Letellier (844555)
Claude Haan (378330)
Stephanie Kreis (378326)

February 2019

Table S1. Kinase inhibitor library screening. A commercial kinase inhibitor library of 274 compounds...

Additional file 2: Figure S1. of PLX8394, a new generation BRAF inhibitor, selectively inhibits BRAF in colonic adenocarcinoma cells and prevents paradoxical MAPK pathway activation

Candani Tutuka (4181644)
Miles Andrews (3763117)
John Mariadason (94966)
Paul Ioannidis (4181647)
Christopher Hudson (383417)
Jonathan Cebon (124236)
Andreas Behren (3460808)

June 2017

The effect of vemurafenib and PLX8394 on the BRAF V600E melanoma cell line LM-MEL-64 and the BRAF wt...

Additional file 4: Table S1. of Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cells

Sebastian Halbach (3477770)
Zehan Hu (3477767)
Christine Gretzmeier (1874908)
Julia Ellermann (3477764)
Franziska Wöhrle (3477776)
Jörn Dengjel (147670)
Tilman Brummer (107550)

February 2016

Anti-GAB2 IP of Imatinib vs DMSO treated cells. Experiment 1 and 2 are averages of two replicates ea...

Additional file 5: of Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Christiane Margue (378328)
Demetra Philippidou (378327)
Ines Kozar (5825252)
Giulia Cesi (387421)
Paul Felten (757793)
Dagmar Kulms (150425)
Elisabeth Letellier (844555)
Claude Haan (378330)
Stephanie Kreis (378326)

February 2019

Figure S3. BRAF inhibitors in combination with selected kinase inhibitors synergistically inhibit pr...

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

Eszter Molnár
Dominika Rittler
Marcell Baranyi
Michael Grusch
Walter Berger
Balázs Döme
József Tóvári
Clemens Aigner
József Tímár
Tamás Garay
Balázs Hegedűs

May 2018

Abstract Background Currently, there are no available targeted therapy options for non-V600 BRAF mut...

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

Molnár, Eszter
Rittler D
Baranyi, Marcell
Grusch M
Berger W
Döme, Balázs
Tóvári, József
Aigner C
Tímár, József
Garay, Tamás
Hegedűs, Balázs

May 2018

BACKGROUND: Currently, there are no available targeted therapy options for non-V600 BRAF mutated tum...

Additional file 3: of Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer

Murugan Kalimutho (6375365)
Debottam Sinha (6375368)
Deepak Mittal (4967743)
Sriganesh Srihari (3542939)
Devathri Nanayakkara (6375371)
Shagufta Shafique (759049)
Prahlad Raninga (6375374)
Purba Nag (6375377)
Kate Parsons (6375380)
Kum Khanna (3588107)

February 2019

Figure S2: (A) Hs578T cells were exposed to different concentrations of MEK1/2 inhibitor (AZD6244) a...

Additional file 2: of A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

Tonći Šuštić (6016781)
Sake van Wageningen (3583763)
Evert Bosdriesz (6016790)
Robert Reid (3433565)
John Dittmar (6016793)
Cor Lieftink (6016799)
Roderick Beijersbergen (6016805)
Lodewyk Wessels (66823)
Rodney Rothstein (17038)
René Bernards (82847)

November 2018

Figure S1. Genome-wide synthetic lethal screens with RAS1(V19) and RAS2(V19) identify overlapping se...

Additional file 2: of Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

Eszter Molnár (688832)
Dominika Rittler (5186183)
Marcell Baranyi (5186186)
Michael Grusch (470621)
Walter Berger (194987)
Balázs Döme (470625)
József Tóvári (168476)
Clemens Aigner (5186177)
József Tímár (5186180)
Tamás Garay (688831)
Balázs Hegedűs (470624)

May 2018

Figure S2. Analysis of cell cycle after treatment with selumetinib or sorafenib and combination. Cel...

Additional file 3: of Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Christiane Margue (378328)
Demetra Philippidou (378327)
Ines Kozar (5825252)
Giulia Cesi (387421)
Paul Felten (757793)
Dagmar Kulms (150425)
Elisabeth Letellier (844555)
Claude Haan (378330)
Stephanie Kreis (378326)

February 2019

Figure S1. Dose-response curves of selected kinase inhibitors in parental and BRAFi-resistant A375 c...

Additional file 4: of Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Christiane Margue (378328)
Demetra Philippidou (378327)
Ines Kozar (5825252)
Giulia Cesi (387421)
Paul Felten (757793)
Dagmar Kulms (150425)
Elisabeth Letellier (844555)
Claude Haan (378330)
Stephanie Kreis (378326)

February 2019

Figure S2. Dose-response curves of selected kinase inhibitors in parental and BRAFi-resistant IGR37 ...

Additional file 1: of Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models

Anais Del Curatolo (5495051)
Fabiana Conciatori (5495060)
Ursula Cesta Incani (5495054)
Chiara Bazzichetto (5495066)
Italia Falcone (5495063)
Vincenzo Corbo (242342)
Sabrina DâAgosto (5495069)
Adriana Eramo (129964)
Giovanni Sette (129952)
Isabella Sperduti (85365)
Teresa De Luca (1773619)
Mirko Marabese (399904)
Senji Shirasawa (268173)
Ruggero De Maria (129963)
Aldo Scarpa (242345)
Massimo Broggini (74308)
Donatella Del Bufalo (132771)
Francesco Cognetti (510876)
Michele Milella (725941)
Ludovica Ciuffreda (5495057)

July 2018

Supplementary Methods. Figure S1. RAF inhibition induces BRAF/CRAF heterodimerization in KRAS-mut co...

Additional file 1: Figure S1. of Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cells

Sebastian Halbach (3477770)
Zehan Hu (3477767)
Christine Gretzmeier (1874908)
Julia Ellermann (3477764)
Franziska Wöhrle (3477776)
Jörn Dengjel (147670)
Tilman Brummer (107550)

February 2016

(A/B) Ba/F3 vector cells and cells transformed with pBABE Bcr-Abl were exposed to the indicated inhi...

Additional file 3: Figure S2. of PLX8394, a new generation BRAF inhibitor, selectively inhibits BRAF in colonic adenocarcinoma cells and prevents paradoxical MAPK pathway activation

Candani Tutuka (4181644)
Miles Andrews (3763117)
John Mariadason (94966)
Paul Ioannidis (4181647)
Christopher Hudson (383417)
Jonathan Cebon (124236)
Andreas Behren (3460808)

June 2017

The effect of BRAF inhibitors vemurafenib and PLX8394 on BRAF wt / KRAS G13D cell line HCT 116. Cell...

Additional file 8: of Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Christiane Margue (378328)
Demetra Philippidou (378327)
Ines Kozar (5825252)
Giulia Cesi (387421)
Paul Felten (757793)
Dagmar Kulms (150425)
Elisabeth Letellier (844555)
Claude Haan (378330)
Stephanie Kreis (378326)

February 2019

Figure 6. Dose-response curves of selected kinase inhibitors in the presence or absence of BRAF inhi...

Additional file 1: of Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Christiane Margue (378328)
Demetra Philippidou (378327)
Ines Kozar (5825252)
Giulia Cesi (387421)
Paul Felten (757793)
Dagmar Kulms (150425)
Elisabeth Letellier (844555)
Claude Haan (378330)
Stephanie Kreis (378326)

February 2019

Table S1. Kinase inhibitor library screening. A commercial kinase inhibitor library of 274 compounds...

Additional file 2: Figure S1. of PLX8394, a new generation BRAF inhibitor, selectively inhibits BRAF in colonic adenocarcinoma cells and prevents paradoxical MAPK pathway activation

Candani Tutuka (4181644)
Miles Andrews (3763117)
John Mariadason (94966)
Paul Ioannidis (4181647)
Christopher Hudson (383417)
Jonathan Cebon (124236)
Andreas Behren (3460808)

June 2017

The effect of vemurafenib and PLX8394 on the BRAF V600E melanoma cell line LM-MEL-64 and the BRAF wt...

Additional file 4: Table S1. of Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cells

Sebastian Halbach (3477770)
Zehan Hu (3477767)
Christine Gretzmeier (1874908)
Julia Ellermann (3477764)
Franziska Wöhrle (3477776)
Jörn Dengjel (147670)
Tilman Brummer (107550)

February 2016

Anti-GAB2 IP of Imatinib vs DMSO treated cells. Experiment 1 and 2 are averages of two replicates ea...

Additional file 5: of Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Christiane Margue (378328)
Demetra Philippidou (378327)
Ines Kozar (5825252)
Giulia Cesi (387421)
Paul Felten (757793)
Dagmar Kulms (150425)
Elisabeth Letellier (844555)
Claude Haan (378330)
Stephanie Kreis (378326)

February 2019

Figure S3. BRAF inhibitors in combination with selected kinase inhibitors synergistically inhibit pr...

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

Eszter Molnár
Dominika Rittler
Marcell Baranyi
Michael Grusch
Walter Berger
Balázs Döme
József Tóvári
Clemens Aigner
József Tímár
Tamás Garay
Balázs Hegedűs

May 2018

Abstract Background Currently, there are no available targeted therapy options for non-V600 BRAF mut...

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

Molnár, Eszter
Rittler D
Baranyi, Marcell
Grusch M
Berger W
Döme, Balázs
Tóvári, József
Aigner C
Tímár, József
Garay, Tamás
Hegedűs, Balázs

May 2018

BACKGROUND: Currently, there are no available targeted therapy options for non-V600 BRAF mutated tum...

Additional file 3: of Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer

Murugan Kalimutho (6375365)
Debottam Sinha (6375368)
Deepak Mittal (4967743)
Sriganesh Srihari (3542939)
Devathri Nanayakkara (6375371)
Shagufta Shafique (759049)
Prahlad Raninga (6375374)
Purba Nag (6375377)
Kate Parsons (6375380)
Kum Khanna (3588107)

February 2019

Figure S2: (A) Hs578T cells were exposed to different concentrations of MEK1/2 inhibitor (AZD6244) a...

Additional file 2: of A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

Tonći Šuštić (6016781)
Sake van Wageningen (3583763)
Evert Bosdriesz (6016790)
Robert Reid (3433565)
John Dittmar (6016793)
Cor Lieftink (6016799)
Roderick Beijersbergen (6016805)
Lodewyk Wessels (66823)
Rodney Rothstein (17038)
René Bernards (82847)

November 2018

Figure S1. Genome-wide synthetic lethal screens with RAS1(V19) and RAS2(V19) identify overlapping se...

Additional file 1: of Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

Abstract

Extracted data

Additional file 1: of Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

Abstract

Extracted data

Related items

Related items