Anterior and posterior abnormalities occur concurrently or not at all.

<p>Slit lamp images, fundus exams, and gross optic nerve morphology was assessed sequentially in 42 eyes of <i>Bmp4</i>^<i>Δ/+</i> mice. 30/42 eyes displayed each of the following: ASD, abnormal vasculature, and absence of an optic nerve <b>(A-C, A’-C’, A”-C”)</b>. The remaining 12 eyes appeared normal in each category <b>(D-D”)</b>. None of the eyes examined presented with only anterior segment dysgenesis or only posterior segment dysgenesis <b>(E)</b>. An additional cohort (n = 6 eyes; 3 phenotypically abnormal and 3 with phenotypically normal based upon <i>in vivo</i> imaging) was assessed with plastic histology following slit lamp and fundus examination. Representative images from the same animal illustrate that the phenotypic presentation of the anterior segment <b>(F, G)</b> always predicts the presence or absence of morphological disruption in the posterior segment <b>(F”, F”‘, G”, G”‘)</b>. Arrows represent: hypoplastic ciliary body (#1, <b>F’)</b>, iridocorneal adhesion (#2, <b>F’</b>), persistent hyaloid vasculature (#3, <b>F”</b>), disrupted retinal lamination (#4, <b>F”</b>), and obstructed optic nerve exit (#5, <b>F”‘</b>). Scale bars represent 100μ.