Delayed onset and reduced susceptibility to diabetes in paquinimod-treated NOD mice.

<p>Incidence of diabetes in mice treated with different doses of paquinimod (mg/kg/day; n = 10 for each dose) or vehicle (Ctrl; n = 20) from 10 to 20w of age A) or 15 to 38 w of age B). In the experiment in C) and D) NOD mice were treated with 1mg/kg/day of paquinimod or vehicle starting at 15w of age and two groups of mice (treated n = 10; controls n = 10) were sacrificed after 5 weeks of treatment (20w of age) C), and two additional groups (treated n = 10; controls n = 10) were sacrificed after 15 weeks of treatment (30w of age). Incidence of diabetes in treated groups compared to the control group (**, <i>p <</i> 0.01, ***, <i>p <</i> 0.001, by Mann Whitney U test).