<p>PRCCs are shown between model parameters (mutation frequency, number of resistance mutations, relative fitness of resistant Mtb, and number of compensatory mutations) and model outputs of interest (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0196322#pone.0196322.t001" target="_blank">Table 1</a>) (Fraction of Granulomas with INH (A) or RIF (C) resistant Mtb; and the number of INH (B) or RIF (D) resistant Mtb per granuloma). Dotted lines show PRCCs with p-values of 0.05, PRCCs outside these lines are significant.</p
<p>(A) The change in the saddle-node bifurcation point in response to a 20% increase or decrease of ...
<p>PRCC values for all parameters resulted significant against the target variables. Grey blocks ind...
<p>Resistance was assessed according to the disease index: Highly resistant = 0.0–10.0; Resistant = ...
<p>(A) Cellular growth sensitivity to each of the parameters, perturbed by 10%. Parameter definition...
a<p>Partial rank correlation coefficient (PRCC) indicates the degree of monotonicity between a speci...
<p>(a) Heatmap for the probability of initiation for a single crypt for ranges of parameters of <i>α...
<p>Results for all INH-resistant strains are grouped, as well as the results for are wildtype strain...
LHS-PRCC results for peak magnitude of infected individuals and total number of infections of system...
<p>A broad compilation of MDR-TB global epidemiological statistics represents the estimated percenta...
<p>Plots of absolute values of sensitivity coefficients for the three parameters for <b>(A)</b> the ...
<p>The formation of virtual granulomas is an emergent behavior of the model (A). A representative gr...
For each pathogen, we show the three most important parameters with the associated partial rank corr...
<p>(A) Sensitivities of BRAF wild type and mutant samples to three BRAF inhibitors, i.e., AZ628, PLX...
<p>Integral mutation burden is calculated by using logistic regression model, which predicted the pr...
<p>Shown are the results for parameter 6 (<i>Values[J20ppx]</i>) under parameter variations of (A) ...
<p>(A) The change in the saddle-node bifurcation point in response to a 20% increase or decrease of ...
<p>PRCC values for all parameters resulted significant against the target variables. Grey blocks ind...
<p>Resistance was assessed according to the disease index: Highly resistant = 0.0–10.0; Resistant = ...
<p>(A) Cellular growth sensitivity to each of the parameters, perturbed by 10%. Parameter definition...
a<p>Partial rank correlation coefficient (PRCC) indicates the degree of monotonicity between a speci...
<p>(a) Heatmap for the probability of initiation for a single crypt for ranges of parameters of <i>α...
<p>Results for all INH-resistant strains are grouped, as well as the results for are wildtype strain...
LHS-PRCC results for peak magnitude of infected individuals and total number of infections of system...
<p>A broad compilation of MDR-TB global epidemiological statistics represents the estimated percenta...
<p>Plots of absolute values of sensitivity coefficients for the three parameters for <b>(A)</b> the ...
<p>The formation of virtual granulomas is an emergent behavior of the model (A). A representative gr...
For each pathogen, we show the three most important parameters with the associated partial rank corr...
<p>(A) Sensitivities of BRAF wild type and mutant samples to three BRAF inhibitors, i.e., AZ628, PLX...
<p>Integral mutation burden is calculated by using logistic regression model, which predicted the pr...
<p>Shown are the results for parameter 6 (<i>Values[J20ppx]</i>) under parameter variations of (A) ...
<p>(A) The change in the saddle-node bifurcation point in response to a 20% increase or decrease of ...
<p>PRCC values for all parameters resulted significant against the target variables. Grey blocks ind...
<p>Resistance was assessed according to the disease index: Highly resistant = 0.0–10.0; Resistant = ...