Permeability studies of Caco-2 layers with different compounds.

<p>(A) Schematic drawing of membrane enhancer and drugs flowed across the Caco-2 cells cultured in the microfluidic device. Insert is an enlarged schematic view of disrupted tight junctions upon co-administering the membrane enhancer TDM. (B) Comparison of permeability profiles of different compounds with or without TDM experimented on Caco-2 layers cultured in microfluidic device versus Transwell: (i) mannitol, (ii) FD4 and (iii) insulin. Data points represent mean ± SEM (n = 4; *p ≤ 0.02, **** p < 0.0001 and ns = not significant).