<p>Predictive testing to characterise substances for their skin sensitisation potential has historically been based on animal models such as the Local Lymph Node Assay (LLNA) and the Guinea Pig Maximisation Test (GPMT). In recent years, EU regulations, have provided a strong incentive to develop non-animal alternatives, such as expert systems software. Here we selected three different types of expert systems: VEGA (statistical), Derek Nexus (knowledge-based) and TIMES-SS (hybrid), and evaluated their performance using two large sets of animal data: one set of 1249 substances from eChemportal and a second set of 515 substances from NICEATM. A model was considered successful at predicting skin sensitisation potential if it had at least the sa...
The Dermal Sensitisation Thresholds (DST) are Thresholds of Toxicological Concern, which can be used...
Skin sensitization is the development of the allergic contact dermatitis caused by chemicals. Regula...
Abstract Safety evaluation for medical devices includes the toxicity assessment of chemicals used in...
Skin sensitisation potential is an endpoint that needs to be assessed within the framework of existi...
Industrial chemicals need to be assessed for their potential to cause skin sensitization. The Europe...
As part of a European Chemicals Bureau contract relating to the evaluation of (Q)SARs for toxicologi...
<p>Cosmetics Europe, the European Trade Association for the cosmetics and personal care industry, is...
In vivo skin sensitization assays have to be provided by applicants to the competent authorities in ...
Poster presentation at American Society for Cellular and Computational Toxicology (ASCCT) Meeting Se...
AbstractSensitization, the prerequisite event in the development of allergic contact dermatitis, is ...
<p>Skin sensitization is a toxicity endpoint of widespread concern, for which the mechanistic unders...
AbstractSince March 2013, it is no longer possible to market in the European Union (EU) cosmetics co...
<p>Public domain and commercial <i>in silico</i> tools were compared for their performance in predic...
The TImes MEtabolism Simulator platform used for predicting Skin Sensitization (TIMES-SS) is a hybri...
[[abstract]]Skin sensitization is an important regulatory endpoint associated with allergic contact ...
The Dermal Sensitisation Thresholds (DST) are Thresholds of Toxicological Concern, which can be used...
Skin sensitization is the development of the allergic contact dermatitis caused by chemicals. Regula...
Abstract Safety evaluation for medical devices includes the toxicity assessment of chemicals used in...
Skin sensitisation potential is an endpoint that needs to be assessed within the framework of existi...
Industrial chemicals need to be assessed for their potential to cause skin sensitization. The Europe...
As part of a European Chemicals Bureau contract relating to the evaluation of (Q)SARs for toxicologi...
<p>Cosmetics Europe, the European Trade Association for the cosmetics and personal care industry, is...
In vivo skin sensitization assays have to be provided by applicants to the competent authorities in ...
Poster presentation at American Society for Cellular and Computational Toxicology (ASCCT) Meeting Se...
AbstractSensitization, the prerequisite event in the development of allergic contact dermatitis, is ...
<p>Skin sensitization is a toxicity endpoint of widespread concern, for which the mechanistic unders...
AbstractSince March 2013, it is no longer possible to market in the European Union (EU) cosmetics co...
<p>Public domain and commercial <i>in silico</i> tools were compared for their performance in predic...
The TImes MEtabolism Simulator platform used for predicting Skin Sensitization (TIMES-SS) is a hybri...
[[abstract]]Skin sensitization is an important regulatory endpoint associated with allergic contact ...
The Dermal Sensitisation Thresholds (DST) are Thresholds of Toxicological Concern, which can be used...
Skin sensitization is the development of the allergic contact dermatitis caused by chemicals. Regula...
Abstract Safety evaluation for medical devices includes the toxicity assessment of chemicals used in...