Increased expression of <i>IGF2</i> transcripts in TSC2— human LAM cells and <i>Tsc2</i><sup><i>-/-</i></sup> MEFs.
- Blanca E. Himes (153105)
- Kseniya Obraztsova (5215778)
- Lurong Lian (436174)
- Maya Shumyatcher (5215781)
- Ryan Rue (5215775)
- Elena N. Atochina-Vasserman (511732)
- Stella K. Hur (4875787)
- Marisa S. Bartolomei (328035)
- Jilly F. Evans (2138905)
- Vera P. Krymskaya (188111)
Publication date
May 2018
DOIAbstract
<p>(A) TSC2 levels in human TSC2-null LAM 621–102 cells (TSC2—) cells and TSC2 re-expressing 621–103 LAM (TSC2++) cells. (B) RNA-Seq results show increased <i>IGF2</i> transcripts per kilobase million (TPM) in TSC2— cells. (C) Corresponding plot of mapped reads along the hg38 reference genome corresponding to <i>IGF2</i>. (D) Verification that <i>Tsc2</i> is not expressed in <i>Tsc2</i><sup><i>-/-</i></sup> MEFs. (E) RNA-Seq results show increased <i>Igf2</i> TPMs in <i>Tsc2</i><sup><i>-/-</i></sup> vs. <i>Tsc2</i><sup><i>+/+</i></sup> MEFs. (F) Corresponding plot of mapped reads along the mm10 reference genome corresponding to <i>Igf2</i>.</p
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