Effect of freezing and locomotion durations on contextual fear conditioning in Experiment 2.

<p>OVX mice were implanted s.c. with a Silastic capsule containing either vehicle (EB0L), 0.05 μg/0.1 ml (EB0.05L), 0.5 μg/0.1 ml (EB0.5L), 5 μg/0.1 ml (EB5L), or 50 μg/0.1 ml (EB50L) 14 days before conditioning. Mean (± SEM) duration of freezing (A) and locomotion (B) in the 10 min test conducted 24 h after conditioning. Mice treated with EB50L showed a significantly longer freezing time compared with control (<i>p</i> < 0.05) and EB5L (<i>p</i> < 0.05) mice. EB50L mice also displayed a significantly shorter locomotion time compared to control mice (<i>p</i> < 0.05). Significant differences are denoted by an asterisk; *<i>p</i> < 0.05.