Respiratory function and creatine kinase levels in <i>dy</i>^<i>2J</i><i>/dy</i>^<i>2J</i> mice.

<p><b>(a)</b> Respiration rate was significantly lower (<i>P</i><0.001) in <i>dy</i>^<i>2J</i><i>/dy</i>^<i>2J</i> mice at 15 and 34 weeks of age, as compared to wild type mice (WT). <i>Dy</i>^<i>2J</i><i>/dy</i>^<i>2J</i> mice aged 34 weeks showed a significantly lower (<i>P</i><0.05) respiration rate than 15 weeks old mice, while no differences were found with age in wild type mice. <b>(b)</b> Respiration amplitude normalized to body weight was significantly higher (<i>P</i><0.001) in <i>dy</i>^<i>2J</i><i>/dy</i>^<i>2J</i> mice at 15 and 34 weeks of age, as compared to wild type mice. No differences in normalized respiration amplitude were found with age and between genders in wild type and <i>dy</i>^<i>2J</i><i>/dy</i>^<i>2J</i> mice. Males are indicated by squares and females by circles. <b>(c)</b> Creatine kinase levels were significantly higher (<i>P</i><0.01) in females <i>dy</i>^<i>2J</i><i>/dy</i>^<i>2J</i> and wild type mice at four and eight weeks of age. * Indicates a significant difference. Error bars represent ± SEM, n = 6 per genotype per gender.