PKR modulates abnormal brain signaling in experimental obesity - Fig 3

<p><b>(A)</b> Western blot of PKR showing the absence of PKR in the cortex of PKR^-/- mice. <b>(B)</b> Western blot analysis of peIF2alpha and eIF2alpha in cortex of mice. <b>(C)</b> Histogram of the ratio peIF2alpha/eIF2alpha showing a significant increase in the cortex of WT HFD mice (<i>p</i> = 0.0167). Error bars = SEM. <b>(D)</b> Western blot analysis of pJNK and JNK in cortex of mice. <b>(E)</b> Histogram of the ratio pJNK/JNK showing a significant increase in the cortex of WT HFD mice. Error bars = SEM. <b>(F)</b> Immunostaining of pJNK in mice cortex and histogram of level of pJNK in the cortex of mice showing a significant increase of pJNK load in the cortex of WT HFD mice. Error bars = SEM. (n = 5).