<p><b>(A)</b> Illustration of Iba1 immunostaining in the cortical grey matter in WT and PKR<sup>-/-</sup> mice control or treated by HFD. Scale bar = 50μm. <b>(B)</b> Histogram of level of Iba1 protein load in the cortical grey matter of WT and PKR<sup>-/-</sup> mice after 16 weeks of HFD. No significant modification of Iba1 expression is observed in both strains. Error bars = SEM. <b>(C)</b> Histogram of level of TNFalpha in the cortex and serum of WT and PKR<sup>-/-</sup> mice after 16 weeks of HFD. (n = 5).</p
Additional file 3: Figure S2. Effects of a HFD on insulin resistance. Fasting blood glucose (A) in m...
<p><b>A.</b> The area of F4/80 staining in the liver measured as arbitrary units (AU) was significan...
Binge eating is a characteristic symptom observed in obese individuals that is related to dysfunctio...
<p><b>(A)</b> Western blot of PKR showing the absence of PKR in the cortex of PKR<sup>-/-</sup> mice...
<p><b>(A)</b> Western blot analysis of pIRS1 and IRS1 in cortex of mice. <b>(B)</b> Histogram of the...
<p><b>(A)</b> Evolution of total body weight on control diet or HFD in WT and PKR<sup>-/-</sup> mice...
Metabolic disorders including obesity and type 2 diabetes are known to be associated with chronic in...
Metabolic disorders including obesity and type 2 diabetes are known to be associated with chronic in...
EMD mice showed exacerbated hypothalamic inflammation. (A) Higher expression of Iba-1 was observed i...
Additional file 1: Figure S1. Effects of a HFD on obesity-related phenotypes. Body weight (A) and ex...
<p>Growth curves of f/f and KO mice fed LFD or HFD for 33 weeks (age 5–38 weeks). Body weight (BW) a...
Additional file 4: Figure S3. Effects of a HFD on KA-induced hippocampal COX-2 and iNOS expression. ...
<p>Protein expression of the pro-inflammatory cytokines TNF-α, IL-6 and IL-1β, as well as the inflam...
International audienceIn humans, obesity is associated with brain inflammation, glial reactivity, an...
<div><p>High-fat diet (HFD)-induced obesity is associated with insulin resistance, which may affect ...
Additional file 3: Figure S2. Effects of a HFD on insulin resistance. Fasting blood glucose (A) in m...
<p><b>A.</b> The area of F4/80 staining in the liver measured as arbitrary units (AU) was significan...
Binge eating is a characteristic symptom observed in obese individuals that is related to dysfunctio...
<p><b>(A)</b> Western blot of PKR showing the absence of PKR in the cortex of PKR<sup>-/-</sup> mice...
<p><b>(A)</b> Western blot analysis of pIRS1 and IRS1 in cortex of mice. <b>(B)</b> Histogram of the...
<p><b>(A)</b> Evolution of total body weight on control diet or HFD in WT and PKR<sup>-/-</sup> mice...
Metabolic disorders including obesity and type 2 diabetes are known to be associated with chronic in...
Metabolic disorders including obesity and type 2 diabetes are known to be associated with chronic in...
EMD mice showed exacerbated hypothalamic inflammation. (A) Higher expression of Iba-1 was observed i...
Additional file 1: Figure S1. Effects of a HFD on obesity-related phenotypes. Body weight (A) and ex...
<p>Growth curves of f/f and KO mice fed LFD or HFD for 33 weeks (age 5–38 weeks). Body weight (BW) a...
Additional file 4: Figure S3. Effects of a HFD on KA-induced hippocampal COX-2 and iNOS expression. ...
<p>Protein expression of the pro-inflammatory cytokines TNF-α, IL-6 and IL-1β, as well as the inflam...
International audienceIn humans, obesity is associated with brain inflammation, glial reactivity, an...
<div><p>High-fat diet (HFD)-induced obesity is associated with insulin resistance, which may affect ...
Additional file 3: Figure S2. Effects of a HFD on insulin resistance. Fasting blood glucose (A) in m...
<p><b>A.</b> The area of F4/80 staining in the liver measured as arbitrary units (AU) was significan...
Binge eating is a characteristic symptom observed in obese individuals that is related to dysfunctio...