SOD1^G93A mice have a lower hind limb muscle mass than Ntg controls already at a presymptomatic stage of the disease.

<p>(A-B) Grip strength as latency to fall (sec) and body weights (g) in Ntg and SOD1^G93A mice are reported from 11 to 22 weeks of age (n = 10 per group). Data are expressed as mean ± SEM. *, p < 0.05 by two-way ANOVA for repeated measures (the interaction between genotype and time was significant in A and B with p < 0.0001), Bonferroni’s post-hoc test. (C-D) The weight of TA (C) and Gastrocnemius (GC) (D) was measured in Ntg and SOD1^G93A mice at 12, 14, 17 and 20 weeks of age (n = 5 for each group). The weight of TA and GC was lower in SOD1^G93A mice than age-matched Ntg controls already at a presymptomatic stage of the disease (12 weeks of age). Muscle weight was expressed in mg. Decrease in % was reported with respect to Ntg mice at 12 weeks of age. Data (mean ± SEM) were significantly different (p < 0.05), by one-way ANOVA, Newman-Keuls <i>post-hoc</i> test: *, <i>versus</i> Ntg; #, <i>versus</i> 12-week old SOD1^G93A; °, <i>versus</i> 14-week old SOD1^G93A;§, <i>versus</i> 17-week old SOD1^G93A mice.