Dynamic changes of viral replication factories with ACV or GCV treatment.

<p>EBV B95-8 bacmid 2089 infected 293 cells were transfected with Zta expression vector (+Z) to induce EBV lytic replication and mock-treated or treated with ACV (acyclovir, 25 μg/ml) or GCV (ganciclovir, 5 μg/ml) to block viral replication at 24 hr or 48 hr post-induction. Both treated and untreated cells were stained for RNA Pol II (Red) and BMRF1 (Green) at 96 hr post transfection. Arrows indicate magnified cells in each panel.