Additional file 3: of The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease
- Paul Cheng-Hathaway (5331557)
- Erin Reed-Geaghan (5331551)
- Taylor Jay (365371)
- Brad Casali (5331539)
- Shane Bemiller (4516153)
- Shweta Puntambekar (5331545)
- Victoria von Saucken (5331548)
- Roxanne Williams (5331542)
- J. Karlo (5331554)
- Miguel Moutinho (289537)
- Guixiang Xu (4516174)
- Richard Ransohoff (4516159)
- Bruce Lamb (449614)
- Gary Landreth (233765)
Publication date
June 2018
DOIAbstract
Figure S2. (A) IBA1+ cell number per plaque was assessed relative to plaque size in cortex from APPPS1–21;Trem2+/+ (n = 4), APPPS1–21;Trem2+/− (n = 6), and APPPS1–21;Trem2 +/R47H (n = 4) mice. Data are presented as mean ± SEM. (B) Inflammation-related genes were assessed in cortical and (C) hippocampal lysates from APPPS1–21;Trem2+/+ (n = 15), APPPS1–21;Trem2+/− (n = 12), and APPPS1–21;Trem2 +/R47H (n = 10) mice. Data are presented as fold change normalized gene expression,*p < 0.05, **p < 0.01, ****p < 0.0001. (TIF 9131 kb
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