In vivo EGFR targeted imaging.

<p>(A) In vivo fluorescence images of an EGFR- (upper) and EGFR+ (lower) tumor bearing mouse injected with 50 μg of Pan-ICG. EGFR+ lymph node metastases (white arrow heads) showed high fluorescence signals while no signals from EGFR- ones were seen. On both images, the liver showed high signals with non-specific accumulations. (B) Comparison of the fluorescence signal ratio of lesion to liver between EGFR+ and—lymph node metastases 48 hours after injection of 50 μg Pan-ICG. The signal ratio was significantly higher in EGFR+ lymph node metastases than in EGFR- ones (<i>p</i>< 0.05).