<p>Upon loss of MIF expression in the tumor, cancer cells undergo ICD. This leads to an increased abundance and activation of DCs in the tumor microenvironment, resulting in an enhanced T cell-mediated anti-tumor immune response through secretion of IFNgamma in the tumor microenvironment.</p
<p>(1) Cancer cells produce factors that attract immune cells, primarily macrophages and natural kil...
Administration of anti-CD25 mAb before an aggressive murine breast tumor inoculation provoked effect...
Tumor-specifi c cytotoxic T cells unleashed by the blockade of immune checkpoints have to overcome a...
<div><p>The Macrophage Migration Inhibitory Factor (MIF) is an inflammatory cytokine that is overexp...
<p>1.0 x 10<sup>4</sup> WT or MIF KD 4T1 cells were implanted in the mammary fat pad of female Balb/...
Immunogenic cell death (ICD) elicited by cancer therapy reshapes the tumor immune microenvironment. ...
Cancer immunotherapy is the process of stimulating the host's immune system to kill cancer cells, an...
Immune therapies have significantly improved outcomes for cancer patients with poor prognosis, but m...
The tumor microenvironment comprising of the immune cells and cytokines acts as the 'soil' that nour...
The tumor microenvironment comprising of the immune cells and cytokines acts as the ‘soil’ that nour...
Previous work from our lab and others demonstrates the host-protective functions of individual immun...
While checkpoint blockade immunotherapy (CBT) has demonstrated remarkable clinical efficacy, its suc...
Experimental evidence indicates that mesenchymal stromal cells (MSCs) may regulate tumor microenviro...
Immunogenic cell death (ICD), which is triggered by exposure of tumor cells to a limited range of an...
A class of immune suppressor cells termed myeloid-derived suppressor cells (MDSC) is known to be ele...
<p>(1) Cancer cells produce factors that attract immune cells, primarily macrophages and natural kil...
Administration of anti-CD25 mAb before an aggressive murine breast tumor inoculation provoked effect...
Tumor-specifi c cytotoxic T cells unleashed by the blockade of immune checkpoints have to overcome a...
<div><p>The Macrophage Migration Inhibitory Factor (MIF) is an inflammatory cytokine that is overexp...
<p>1.0 x 10<sup>4</sup> WT or MIF KD 4T1 cells were implanted in the mammary fat pad of female Balb/...
Immunogenic cell death (ICD) elicited by cancer therapy reshapes the tumor immune microenvironment. ...
Cancer immunotherapy is the process of stimulating the host's immune system to kill cancer cells, an...
Immune therapies have significantly improved outcomes for cancer patients with poor prognosis, but m...
The tumor microenvironment comprising of the immune cells and cytokines acts as the 'soil' that nour...
The tumor microenvironment comprising of the immune cells and cytokines acts as the ‘soil’ that nour...
Previous work from our lab and others demonstrates the host-protective functions of individual immun...
While checkpoint blockade immunotherapy (CBT) has demonstrated remarkable clinical efficacy, its suc...
Experimental evidence indicates that mesenchymal stromal cells (MSCs) may regulate tumor microenviro...
Immunogenic cell death (ICD), which is triggered by exposure of tumor cells to a limited range of an...
A class of immune suppressor cells termed myeloid-derived suppressor cells (MDSC) is known to be ele...
<p>(1) Cancer cells produce factors that attract immune cells, primarily macrophages and natural kil...
Administration of anti-CD25 mAb before an aggressive murine breast tumor inoculation provoked effect...
Tumor-specifi c cytotoxic T cells unleashed by the blockade of immune checkpoints have to overcome a...
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